Use Volume To Clean Up The Dirt
Get a whole lotta clean by tuning down.
Often if you want a little less gain (distortion) in your sound you will get a great result by simply turning your volume control down a bit, rather than adjusting amp or pedal settings.
It sometimes gets you sounds that you wouldn't get by adjusting knobs anyway.
The big deal is trying it with your various guitar and amp combinations and it reacts very differently depending on your set up!